Dr. Douglas Paul Martin survives a plane crash nearly unscathed. His remarkable recovery causes concern among his colleagues at the experimental research plant where he works. Dr. Martin becomes increasingly agitated by the air of distrust he feels from his colleagues and wife.
Dr. Martin eventually discovers that he was rescued from his crashing airplane by hostile beings from another planet, who seek to take control of Earth. Dr. Martin fears that no one will be believe his story, and he becomes determined to stop the aliens by himself.
- Peter Graves as Dr. Doug Paul Martin
- James Seay as Col. Banks
- Frank Gerstle as Dr. Curt Kruger
- Barbara Bestar as Ellen Martin
- John Frederick as Deneb / The Tala
- A heavily-edited (and colorized) version of Killers from Space was used in the TV special Attack of the Killer B Movies (co-written by Frank Conniff and starring Elvira). It has not been released on home video or DVD, but can be viewed on YouTube here.
- Killers from Space became a RiffTrax presentation in 2019.