Vaughan appeared in many notable films, including The Magnificent Seven, Bullitt, The Towering Inferno, and Superman III. He also worked extensively on television, including his role on The Man from U.N.C.L.E. as Napoleon Solo.
In addition to his dramatic and action-oriented roles, Robert Vaughn had a strong sense of humor and he played several comedic parts during his career. He hosted the comedy TV series Danger Theater, which also starred Adam West.