As an imperfect clone, Synthia is awkward at human interactions, though she has attempted to display affection for Kinga. During Season 12, Synthia appeared more stable and capable in her interactions, possibly as a result of her use of the intelligence-enhancing invention Algernon.
During the Great Cheesy Movie Circus Tour it was revealed that a clone of Synthia exists, named Mega-Synthia. Synthia and Mega-Synthia appeared in a Zoom meeting during Turkey Day '20, during which they tormented Emily Crenshaw, Jonah Heston, Tom Servo, and Crow. Synthia seemed proud of Mega-Synthia, and the two of them took pleasure in berating the others.
- Synthia is played by Rebecca Hanson, who also provided the voice of Gypsy during the Netflix era.
- Synthia served as the primary Mad during the Watch Out for Snakes! and 30th Anniversary Live Tours.